WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for the enriched GO category are listed in this table. For each GO category, the first row lists its sub-root (biological process, molecular function, or cellular component), category name, and corresponding GO ID.
The second row lists the following statistics:
Finally, genes in the category are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:biological process       Name:protein ubiquitination       ID:GO:0016567
C=535; O=9; E=2.38; R=3.79; rawP=0.0006; adjP=0.0794
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000070950 NA RAD18 RAD18 homolog (S. cerevisiae) 56852 ENSG00000070950
2  ENSG00000013374 NA NUB1 negative regulator of ubiquitin-like proteins 1 51667 ENSG00000013374
3  ENSG00000133606 NA MKRN1 makorin ring finger protein 1 23608 ENSG00000133606
4  ENSG00000161664 NA ASB16 ankyrin repeat and SOCS box containing 16 92591 ENSG00000161664
5  ENSG00000130939 NA UBE4B ubiquitination factor E4B 10277 ENSG00000130939
6  ENSG00000103264 NA FBXO31 F-box protein 31 79791 ENSG00000103264
7  ENSG00000080802 NA CNOT4 CCR4-NOT transcription complex, subunit 4 4850 ENSG00000080802
8  ENSG00000167986 NA DDB1 damage-specific DNA binding protein 1, 127kDa 1642 ENSG00000167986
9  ENSG00000177479 NA ARIH2 ariadne homolog 2 (Drosophila) 10425 ENSG00000177479


Database:biological process       Name:protein modification by small protein conjugation       ID:GO:0032446
C=566; O=9; E=2.51; R=3.58; rawP=0.0008; adjP=0.0794
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000070950 NA RAD18 RAD18 homolog (S. cerevisiae) 56852 ENSG00000070950
2  ENSG00000013374 NA NUB1 negative regulator of ubiquitin-like proteins 1 51667 ENSG00000013374
3  ENSG00000133606 NA MKRN1 makorin ring finger protein 1 23608 ENSG00000133606
4  ENSG00000161664 NA ASB16 ankyrin repeat and SOCS box containing 16 92591 ENSG00000161664
5  ENSG00000130939 NA UBE4B ubiquitination factor E4B 10277 ENSG00000130939
6  ENSG00000103264 NA FBXO31 F-box protein 31 79791 ENSG00000103264
7  ENSG00000080802 NA CNOT4 CCR4-NOT transcription complex, subunit 4 4850 ENSG00000080802
8  ENSG00000167986 NA DDB1 damage-specific DNA binding protein 1, 127kDa 1642 ENSG00000167986
9  ENSG00000177479 NA ARIH2 ariadne homolog 2 (Drosophila) 10425 ENSG00000177479


Database:biological process       Name:purine deoxyribonucleoside triphosphate metabolic process       ID:GO:0009215
C=5; O=2; E=0.02; R=90.03; rawP=0.0002; adjP=0.0794
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000114956 NA DGUOK deoxyguanosine kinase 1716 ENSG00000114956
2  ENSG00000198408 NA MGEA5 meningioma expressed antigen 5 (hyaluronidase) 10724 ENSG00000198408


Database:biological process       Name:response to muscle activity       ID:GO:0014850
C=10; O=2; E=0.04; R=45.02; rawP=0.0009; adjP=0.0794
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000145545 NA SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 6715 ENSG00000145545
2  ENSG00000105221 NA AKT2 v-akt murine thymoma viral oncogene homolog 2 208 ENSG00000105221


Database:biological process       Name:cellular macromolecule catabolic process       ID:GO:0044265
C=695; O=10; E=3.09; R=3.24; rawP=0.0009; adjP=0.0794
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000100226 NA GTPBP1 GTP binding protein 1 9567 ENSG00000100226
2  ENSG00000161011 NA SQSTM1 sequestosome 1 8878 ENSG00000161011
3  ENSG00000104626 NA ERI1 exoribonuclease 1 90459 ENSG00000104626
4  ENSG00000013374 NA NUB1 negative regulator of ubiquitin-like proteins 1 51667 ENSG00000013374
5  ENSG00000130939 NA UBE4B ubiquitination factor E4B 10277 ENSG00000130939
6  ENSG00000103264 NA FBXO31 F-box protein 31 79791 ENSG00000103264
7  ENSG00000118939 NA UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 7347 ENSG00000118939
8  ENSG00000080802 NA CNOT4 CCR4-NOT transcription complex, subunit 4 4850 ENSG00000080802
9  ENSG00000167986 NA DDB1 damage-specific DNA binding protein 1, 127kDa 1642 ENSG00000167986
10  ENSG00000177479 NA ARIH2 ariadne homolog 2 (Drosophila) 10425 ENSG00000177479


Database:biological process       Name:positive regulation of cellular catabolic process       ID:GO:0031331
C=102; O=4; E=0.45; R=8.83; rawP=0.0011; adjP=0.0794
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000100226 NA GTPBP1 GTP binding protein 1 9567 ENSG00000100226
2  ENSG00000177169 NA ULK1 unc-51-like kinase 1 (C. elegans) 8408 ENSG00000177169
3  ENSG00000105221 NA AKT2 v-akt murine thymoma viral oncogene homolog 2 208 ENSG00000105221
4  ENSG00000013374 NA NUB1 negative regulator of ubiquitin-like proteins 1 51667 ENSG00000013374


Database:biological process       Name:deoxyribonucleoside triphosphate metabolic process       ID:GO:0009200
C=12; O=2; E=0.05; R=37.51; rawP=0.0012; adjP=0.0794
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000114956 NA DGUOK deoxyguanosine kinase 1716 ENSG00000114956
2  ENSG00000198408 NA MGEA5 meningioma expressed antigen 5 (hyaluronidase) 10724 ENSG00000198408


Database:biological process       Name:macromolecule catabolic process       ID:GO:0009057
C=893; O=12; E=3.97; R=3.02; rawP=0.0005; adjP=0.0794
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000100226 NA GTPBP1 GTP binding protein 1 9567 ENSG00000100226
2  ENSG00000161011 NA SQSTM1 sequestosome 1 8878 ENSG00000161011
3  ENSG00000104626 NA ERI1 exoribonuclease 1 90459 ENSG00000104626
4  ENSG00000013374 NA NUB1 negative regulator of ubiquitin-like proteins 1 51667 ENSG00000013374
5  ENSG00000198408 NA MGEA5 meningioma expressed antigen 5 (hyaluronidase) 10724 ENSG00000198408
6  ENSG00000130939 NA UBE4B ubiquitination factor E4B 10277 ENSG00000130939
7  ENSG00000103264 NA FBXO31 F-box protein 31 79791 ENSG00000103264
8  ENSG00000118939 NA UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 7347 ENSG00000118939
9  ENSG00000164776 NA PHKG1 phosphorylase kinase, gamma 1 (muscle) 5260 ENSG00000164776
10  ENSG00000080802 NA CNOT4 CCR4-NOT transcription complex, subunit 4 4850 ENSG00000080802
11  ENSG00000167986 NA DDB1 damage-specific DNA binding protein 1, 127kDa 1642 ENSG00000167986
12  ENSG00000177479 NA ARIH2 ariadne homolog 2 (Drosophila) 10425 ENSG00000177479


Database:biological process       Name:purine deoxyribonucleotide metabolic process       ID:GO:0009151
C=9; O=2; E=0.04; R=50.02; rawP=0.0007; adjP=0.0794
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000114956 NA DGUOK deoxyguanosine kinase 1716 ENSG00000114956
2  ENSG00000198408 NA MGEA5 meningioma expressed antigen 5 (hyaluronidase) 10724 ENSG00000198408


Database:biological process       Name:endocytic recycling       ID:GO:0032456
C=11; O=2; E=0.05; R=40.92; rawP=0.0010; adjP=0.0794
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000164715 NA LMTK2 lemur tyrosine kinase 2 22853 ENSG00000164715
2  ENSG00000114520 NA SNX4 sorting nexin 4 8723 ENSG00000114520


Database:molecular function       Name:protein kinase C binding       ID:GO:0005080
C=49; O=3; E=0.21; R=14.18; rawP=0.0012; adjP=0.0589
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000170955 NA PRKCDBP protein kinase C, delta binding protein 112464 ENSG00000170955
2  ENSG00000161011 NA SQSTM1 sequestosome 1 8878 ENSG00000161011
3  ENSG00000105221 NA AKT2 v-akt murine thymoma viral oncogene homolog 2 208 ENSG00000105221


Database:molecular function       Name:protein binding       ID:GO:0005515
C=7337; O=44; E=31.68; R=1.39; rawP=0.0017; adjP=0.0589
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000180104 NA EXOC3 exocyst complex component 3 11336 ENSG00000180104
2  ENSG00000174231 NA PRPF8 PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae) 10594 ENSG00000174231
3  ENSG00000119950 NA MXI1 MAX interactor 1 4601 ENSG00000119950
4  ENSG00000088808 NA PPP1R13B protein phosphatase 1, regulatory subunit 13B 23368 ENSG00000088808
5  ENSG00000169057 NA MECP2 methyl CpG binding protein 2 (Rett syndrome) 4204 ENSG00000169057
6  ENSG00000177169 NA ULK1 unc-51-like kinase 1 (C. elegans) 8408 ENSG00000177169
7  ENSG00000182919 NA C11orf54 chromosome 11 open reading frame 54 28970 ENSG00000182919
8  ENSG00000174442 NA ZWILCH Zwilch, kinetochore associated, homolog (Drosophila) 55055 ENSG00000174442
9  ENSG00000164050 NA PLXNB1 plexin B1 5364 ENSG00000164050
10  ENSG00000119139 NA TJP2 tight junction protein 2 9414 ENSG00000119139
11  ENSG00000012822 NA CALCOCO1 calcium binding and coiled-coil domain 1 57658 ENSG00000012822
12  ENSG00000161011 NA SQSTM1 sequestosome 1 8878 ENSG00000161011
13  ENSG00000114520 NA SNX4 sorting nexin 4 8723 ENSG00000114520
14  ENSG00000183864 NA TOB2 transducer of ERBB2, 2 10766 ENSG00000183864
15  ENSG00000173207 NA CKS1B CDC28 protein kinase regulatory subunit 1B 1163 ENSG00000173207
16  ENSG00000142661 NA MYOM3 myomesin family, member 3 127294 ENSG00000142661
17  ENSG00000105357 NA MYH14 myosin, heavy chain 14, non-muscle 79784 ENSG00000105357
18  ENSG00000103264 NA FBXO31 F-box protein 31 79791 ENSG00000103264
19  ENSG00000136854 NA STXBP1 syntaxin binding protein 1 6812 ENSG00000136854
20  ENSG00000080802 NA CNOT4 CCR4-NOT transcription complex, subunit 4 4850 ENSG00000080802
21  ENSG00000164776 NA PHKG1 phosphorylase kinase, gamma 1 (muscle) 5260 ENSG00000164776
22  ENSG00000099995 NA SF3A1 splicing factor 3a, subunit 1, 120kDa 10291 ENSG00000099995
23  ENSG00000158109 NA TPRG1L tumor protein p63 regulated 1-like 127262 ENSG00000158109
24  ENSG00000164715 NA LMTK2 lemur tyrosine kinase 2 22853 ENSG00000164715
25  ENSG00000184481 NA FOXO4 forkhead box O4 4303 ENSG00000184481
26  ENSG00000105221 NA AKT2 v-akt murine thymoma viral oncogene homolog 2 208 ENSG00000105221
27  ENSG00000013374 NA NUB1 negative regulator of ubiquitin-like proteins 1 51667 ENSG00000013374
28  ENSG00000082641 NA NFE2L1 nuclear factor (erythroid-derived 2)-like 1 4779 ENSG00000082641
29  ENSG00000161664 NA ASB16 ankyrin repeat and SOCS box containing 16 92591 ENSG00000161664
30  ENSG00000085741 NA WNT11 wingless-type MMTV integration site family, member 11 7481 ENSG00000085741
31  ENSG00000130939 NA UBE4B ubiquitination factor E4B 10277 ENSG00000130939
32  ENSG00000116604 NA MEF2D myocyte enhancer factor 2D 4209 ENSG00000116604
33  ENSG00000118939 NA UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 7347 ENSG00000118939
34  ENSG00000139613 NA SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 6601 ENSG00000139613
35  ENSG00000177479 NA ARIH2 ariadne homolog 2 (Drosophila) 10425 ENSG00000177479
36  ENSG00000139112 NA GABARAPL1 GABA(A) receptor-associated protein like 1 23710 ENSG00000139112
37  ENSG00000070950 NA RAD18 RAD18 homolog (S. cerevisiae) 56852 ENSG00000070950
38  ENSG00000170955 NA PRKCDBP protein kinase C, delta binding protein 112464 ENSG00000170955
39  ENSG00000148730 NA EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 1979 ENSG00000148730
40  ENSG00000197724 NA PHF2 PHD finger protein 2 5253 ENSG00000197724
41  ENSG00000100307 NA CBX7 chromobox homolog 7 23492 ENSG00000100307
42  ENSG00000112640 NA PPP2R5D protein phosphatase 2, regulatory subunit B', delta 5528 ENSG00000112640
43  ENSG00000167986 NA DDB1 damage-specific DNA binding protein 1, 127kDa 1642 ENSG00000167986
44  ENSG00000196549 NA MME membrane metallo-endopeptidase 4311 ENSG00000196549


Database:molecular function       Name:DNA secondary structure binding       ID:GO:0000217
C=14; O=2; E=0.06; R=33.08; rawP=0.0016; adjP=0.0589
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000070950 NA RAD18 RAD18 homolog (S. cerevisiae) 56852 ENSG00000070950
2  ENSG00000169057 NA MECP2 methyl CpG binding protein 2 (Rett syndrome) 4204 ENSG00000169057


Database:molecular function       Name:ubiquitin binding       ID:GO:0043130
C=63; O=3; E=0.27; R=11.03; rawP=0.0025; adjP=0.0650
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000118939 NA UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 7347 ENSG00000118939
2  ENSG00000161011 NA SQSTM1 sequestosome 1 8878 ENSG00000161011
3  ENSG00000070950 NA RAD18 RAD18 homolog (S. cerevisiae) 56852 ENSG00000070950


Database:molecular function       Name:small conjugating protein binding       ID:GO:0032182
C=69; O=3; E=0.30; R=10.07; rawP=0.0033; adjP=0.0686
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000118939 NA UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 7347 ENSG00000118939
2  ENSG00000161011 NA SQSTM1 sequestosome 1 8878 ENSG00000161011
3  ENSG00000070950 NA RAD18 RAD18 homolog (S. cerevisiae) 56852 ENSG00000070950


Database:molecular function       Name:polyubiquitin binding       ID:GO:0031593
C=29; O=2; E=0.13; R=15.97; rawP=0.0069; adjP=0.1196
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000161011 NA SQSTM1 sequestosome 1 8878 ENSG00000161011
2  ENSG00000070950 NA RAD18 RAD18 homolog (S. cerevisiae) 56852 ENSG00000070950


Database:molecular function       Name:ligase activity       ID:GO:0016874
C=483; O=6; E=2.09; R=2.88; rawP=0.0177; adjP=0.1306
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000130939 NA UBE4B ubiquitination factor E4B 10277 ENSG00000130939
2  ENSG00000070950 NA RAD18 RAD18 homolog (S. cerevisiae) 56852 ENSG00000070950
3  ENSG00000080802 NA CNOT4 CCR4-NOT transcription complex, subunit 4 4850 ENSG00000080802
4  ENSG00000177479 NA ARIH2 ariadne homolog 2 (Drosophila) 10425 ENSG00000177479
5  ENSG00000133606 NA MKRN1 makorin ring finger protein 1 23608 ENSG00000133606
6  ENSG00000215218 NA UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 134111 ENSG00000215218


Database:molecular function       Name:transcription cofactor activity       ID:GO:0003712
C=466; O=6; E=2.01; R=2.98; rawP=0.0151; adjP=0.1306
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000197724 NA PHF2 PHD finger protein 2 5253 ENSG00000197724
2  ENSG00000012822 NA CALCOCO1 calcium binding and coiled-coil domain 1 57658 ENSG00000012822
3  ENSG00000119950 NA MXI1 MAX interactor 1 4601 ENSG00000119950
4  ENSG00000139613 NA SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 6601 ENSG00000139613
5  ENSG00000169057 NA MECP2 methyl CpG binding protein 2 (Rett syndrome) 4204 ENSG00000169057
6  ENSG00000082641 NA NFE2L1 nuclear factor (erythroid-derived 2)-like 1 4779 ENSG00000082641


Database:molecular function       Name:protein kinase binding       ID:GO:0019901
C=361; O=5; E=1.56; R=3.21; rawP=0.0197; adjP=0.1306
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000170955 NA PRKCDBP protein kinase C, delta binding protein 112464 ENSG00000170955
2  ENSG00000177169 NA ULK1 unc-51-like kinase 1 (C. elegans) 8408 ENSG00000177169
3  ENSG00000184481 NA FOXO4 forkhead box O4 4303 ENSG00000184481
4  ENSG00000161011 NA SQSTM1 sequestosome 1 8878 ENSG00000161011
5  ENSG00000105221 NA AKT2 v-akt murine thymoma viral oncogene homolog 2 208 ENSG00000105221


Database:molecular function       Name:nucleobase-containing compound kinase activity       ID:GO:0019205
C=49; O=2; E=0.21; R=9.45; rawP=0.0190; adjP=0.1306
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000119139 NA TJP2 tight junction protein 2 9414 ENSG00000119139
2  ENSG00000114956 NA DGUOK deoxyguanosine kinase 1716 ENSG00000114956


Database:cellular component       Name:intracellular       ID:GO:0005622
C=12564; O=68; E=54.52; R=1.25; rawP=7.42e-05; adjP=0.0068
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000180104 NA EXOC3 exocyst complex component 3 11336 ENSG00000180104
2  ENSG00000005955 NA GGNBP2 gametogenetin binding protein 2 79893 ENSG00000005955
3  ENSG00000127920 NA GNG11 guanine nucleotide binding protein (G protein), gamma 11 2791 ENSG00000127920
4  ENSG00000088808 NA PPP1R13B protein phosphatase 1, regulatory subunit 13B 23368 ENSG00000088808
5  ENSG00000164050 NA PLXNB1 plexin B1 5364 ENSG00000164050
6  ENSG00000187954 NA CYHR1 cysteine/histidine-rich 1 50626 ENSG00000187954
7  ENSG00000114520 NA SNX4 sorting nexin 4 8723 ENSG00000114520
8  ENSG00000104626 NA ERI1 exoribonuclease 1 90459 ENSG00000104626
9  ENSG00000183864 NA TOB2 transducer of ERBB2, 2 10766 ENSG00000183864
10  ENSG00000105357 NA MYH14 myosin, heavy chain 14, non-muscle 79784 ENSG00000105357
11  ENSG00000117472 NA TSPAN1 tetraspanin 1 10103 ENSG00000117472
12  ENSG00000099995 NA SF3A1 splicing factor 3a, subunit 1, 120kDa 10291 ENSG00000099995
13  ENSG00000100226 NA GTPBP1 GTP binding protein 1 9567 ENSG00000100226
14  ENSG00000105221 NA AKT2 v-akt murine thymoma viral oncogene homolog 2 208 ENSG00000105221
15  ENSG00000082641 NA NFE2L1 nuclear factor (erythroid-derived 2)-like 1 4779 ENSG00000082641
16  ENSG00000161664 NA ASB16 ankyrin repeat and SOCS box containing 16 92591 ENSG00000161664
17  ENSG00000085741 NA WNT11 wingless-type MMTV integration site family, member 11 7481 ENSG00000085741
18  ENSG00000116604 NA MEF2D myocyte enhancer factor 2D 4209 ENSG00000116604
19  ENSG00000139112 NA GABARAPL1 GABA(A) receptor-associated protein like 1 23710 ENSG00000139112
20  ENSG00000070950 NA RAD18 RAD18 homolog (S. cerevisiae) 56852 ENSG00000070950
21  ENSG00000241258 NA CRCP CGRP receptor component 27297 ENSG00000241258
22  ENSG00000182916 NA TCEAL7 transcription elongation factor A (SII)-like 7 56849 ENSG00000182916
23  ENSG00000197724 NA PHF2 PHD finger protein 2 5253 ENSG00000197724
24  ENSG00000196460 NA RFX8 regulatory factor X, 8 731220 ENSG00000196460
25  ENSG00000114956 NA DGUOK deoxyguanosine kinase 1716 ENSG00000114956
26  ENSG00000100307 NA CBX7 chromobox homolog 7 23492 ENSG00000100307
27  ENSG00000145545 NA SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 6715 ENSG00000145545
28  ENSG00000112640 NA PPP2R5D protein phosphatase 2, regulatory subunit B', delta 5528 ENSG00000112640
29  ENSG00000104960 NA PTOV1 prostate tumor overexpressed 1 53635 ENSG00000104960
30  ENSG00000174231 NA PRPF8 PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae) 10594 ENSG00000174231
31  ENSG00000119950 NA MXI1 MAX interactor 1 4601 ENSG00000119950
32  ENSG00000109111 NA SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 6830 ENSG00000109111
33  ENSG00000169057 NA MECP2 methyl CpG binding protein 2 (Rett syndrome) 4204 ENSG00000169057
34  ENSG00000159055 NA MIS18A MIS18 kinetochore protein homolog A (S. pombe) 54069 ENSG00000159055
35  ENSG00000177169 NA ULK1 unc-51-like kinase 1 (C. elegans) 8408 ENSG00000177169
36  ENSG00000182919 NA C11orf54 chromosome 11 open reading frame 54 28970 ENSG00000182919
37  ENSG00000174442 NA ZWILCH Zwilch, kinetochore associated, homolog (Drosophila) 55055 ENSG00000174442
38  ENSG00000119139 NA TJP2 tight junction protein 2 9414 ENSG00000119139
39  ENSG00000012822 NA CALCOCO1 calcium binding and coiled-coil domain 1 57658 ENSG00000012822
40  ENSG00000161011 NA SQSTM1 sequestosome 1 8878 ENSG00000161011
41  ENSG00000213380 NA COG8 component of oligomeric golgi complex 8 84342 ENSG00000213380
42  ENSG00000213995 NA CARKD carbohydrate kinase domain containing 55739 ENSG00000213995
43  ENSG00000198408 NA MGEA5 meningioma expressed antigen 5 (hyaluronidase) 10724 ENSG00000198408
44  ENSG00000142661 NA MYOM3 myomesin family, member 3 127294 ENSG00000142661
45  ENSG00000173207 NA CKS1B CDC28 protein kinase regulatory subunit 1B 1163 ENSG00000173207
46  ENSG00000241852 NA C8orf58 chromosome 8 open reading frame 58 541565 ENSG00000241852
47  ENSG00000103264 NA FBXO31 F-box protein 31 79791 ENSG00000103264
48  ENSG00000164776 NA PHKG1 phosphorylase kinase, gamma 1 (muscle) 5260 ENSG00000164776
49  ENSG00000080802 NA CNOT4 CCR4-NOT transcription complex, subunit 4 4850 ENSG00000080802
50  ENSG00000136854 NA STXBP1 syntaxin binding protein 1 6812 ENSG00000136854
51  ENSG00000127054 NA CPSF3L cleavage and polyadenylation specific factor 3-like 54973 ENSG00000127054
52  ENSG00000079459 NA FDFT1 farnesyl-diphosphate farnesyltransferase 1 2222 ENSG00000079459
53  ENSG00000158109 NA TPRG1L tumor protein p63 regulated 1-like 127262 ENSG00000158109
54  ENSG00000166887 NA VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 23339 ENSG00000166887
55  ENSG00000164715 NA LMTK2 lemur tyrosine kinase 2 22853 ENSG00000164715
56  ENSG00000184481 NA FOXO4 forkhead box O4 4303 ENSG00000184481
57  ENSG00000013374 NA NUB1 negative regulator of ubiquitin-like proteins 1 51667 ENSG00000013374
58  ENSG00000116871 NA MAP7D1 MAP7 domain containing 1 55700 ENSG00000116871
59  ENSG00000130939 NA UBE4B ubiquitination factor E4B 10277 ENSG00000130939
60  ENSG00000139613 NA SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 6601 ENSG00000139613
61  ENSG00000118939 NA UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 7347 ENSG00000118939
62  ENSG00000177479 NA ARIH2 ariadne homolog 2 (Drosophila) 10425 ENSG00000177479
63  ENSG00000163719 NA MTMR14 myotubularin related protein 14 64419 ENSG00000163719
64  ENSG00000124786 NA SLC35B3 solute carrier family 35, member B3 51000 ENSG00000124786
65  ENSG00000173011 NA TADA2B transcriptional adaptor 2B 93624 ENSG00000173011
66  ENSG00000136709 NA WDR33 WD repeat domain 33 55339 ENSG00000136709
67  ENSG00000167986 NA DDB1 damage-specific DNA binding protein 1, 127kDa 1642 ENSG00000167986
68  ENSG00000196549 NA MME membrane metallo-endopeptidase 4311 ENSG00000196549


Database:cellular component       Name:membrane-bounded organelle       ID:GO:0043227
C=9598; O=56; E=41.65; R=1.34; rawP=0.0004; adjP=0.0068
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000180104 NA EXOC3 exocyst complex component 3 11336 ENSG00000180104
2  ENSG00000174231 NA PRPF8 PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae) 10594 ENSG00000174231
3  ENSG00000119950 NA MXI1 MAX interactor 1 4601 ENSG00000119950
4  ENSG00000005955 NA GGNBP2 gametogenetin binding protein 2 79893 ENSG00000005955
5  ENSG00000109111 NA SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 6830 ENSG00000109111
6  ENSG00000088808 NA PPP1R13B protein phosphatase 1, regulatory subunit 13B 23368 ENSG00000088808
7  ENSG00000169057 NA MECP2 methyl CpG binding protein 2 (Rett syndrome) 4204 ENSG00000169057
8  ENSG00000159055 NA MIS18A MIS18 kinetochore protein homolog A (S. pombe) 54069 ENSG00000159055
9  ENSG00000177169 NA ULK1 unc-51-like kinase 1 (C. elegans) 8408 ENSG00000177169
10  ENSG00000182919 NA C11orf54 chromosome 11 open reading frame 54 28970 ENSG00000182919
11  ENSG00000119139 NA TJP2 tight junction protein 2 9414 ENSG00000119139
12  ENSG00000187954 NA CYHR1 cysteine/histidine-rich 1 50626 ENSG00000187954
13  ENSG00000012822 NA CALCOCO1 calcium binding and coiled-coil domain 1 57658 ENSG00000012822
14  ENSG00000161011 NA SQSTM1 sequestosome 1 8878 ENSG00000161011
15  ENSG00000114520 NA SNX4 sorting nexin 4 8723 ENSG00000114520
16  ENSG00000104626 NA ERI1 exoribonuclease 1 90459 ENSG00000104626
17  ENSG00000213380 NA COG8 component of oligomeric golgi complex 8 84342 ENSG00000213380
18  ENSG00000213995 NA CARKD carbohydrate kinase domain containing 55739 ENSG00000213995
19  ENSG00000183864 NA TOB2 transducer of ERBB2, 2 10766 ENSG00000183864
20  ENSG00000198408 NA MGEA5 meningioma expressed antigen 5 (hyaluronidase) 10724 ENSG00000198408
21  ENSG00000173207 NA CKS1B CDC28 protein kinase regulatory subunit 1B 1163 ENSG00000173207
22  ENSG00000241852 NA C8orf58 chromosome 8 open reading frame 58 541565 ENSG00000241852
23  ENSG00000117472 NA TSPAN1 tetraspanin 1 10103 ENSG00000117472
24  ENSG00000136854 NA STXBP1 syntaxin binding protein 1 6812 ENSG00000136854
25  ENSG00000080802 NA CNOT4 CCR4-NOT transcription complex, subunit 4 4850 ENSG00000080802
26  ENSG00000127054 NA CPSF3L cleavage and polyadenylation specific factor 3-like 54973 ENSG00000127054
27  ENSG00000079459 NA FDFT1 farnesyl-diphosphate farnesyltransferase 1 2222 ENSG00000079459
28  ENSG00000099995 NA SF3A1 splicing factor 3a, subunit 1, 120kDa 10291 ENSG00000099995
29  ENSG00000166887 NA VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 23339 ENSG00000166887
30  ENSG00000158109 NA TPRG1L tumor protein p63 regulated 1-like 127262 ENSG00000158109
31  ENSG00000164715 NA LMTK2 lemur tyrosine kinase 2 22853 ENSG00000164715
32  ENSG00000184481 NA FOXO4 forkhead box O4 4303 ENSG00000184481
33  ENSG00000105221 NA AKT2 v-akt murine thymoma viral oncogene homolog 2 208 ENSG00000105221
34  ENSG00000013374 NA NUB1 negative regulator of ubiquitin-like proteins 1 51667 ENSG00000013374
35  ENSG00000082641 NA NFE2L1 nuclear factor (erythroid-derived 2)-like 1 4779 ENSG00000082641
36  ENSG00000130939 NA UBE4B ubiquitination factor E4B 10277 ENSG00000130939
37  ENSG00000116604 NA MEF2D myocyte enhancer factor 2D 4209 ENSG00000116604
38  ENSG00000118939 NA UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 7347 ENSG00000118939
39  ENSG00000139613 NA SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 6601 ENSG00000139613
40  ENSG00000177479 NA ARIH2 ariadne homolog 2 (Drosophila) 10425 ENSG00000177479
41  ENSG00000139112 NA GABARAPL1 GABA(A) receptor-associated protein like 1 23710 ENSG00000139112
42  ENSG00000070950 NA RAD18 RAD18 homolog (S. cerevisiae) 56852 ENSG00000070950
43  ENSG00000124786 NA SLC35B3 solute carrier family 35, member B3 51000 ENSG00000124786
44  ENSG00000173011 NA TADA2B transcriptional adaptor 2B 93624 ENSG00000173011
45  ENSG00000241258 NA CRCP CGRP receptor component 27297 ENSG00000241258
46  ENSG00000197724 NA PHF2 PHD finger protein 2 5253 ENSG00000197724
47  ENSG00000182916 NA TCEAL7 transcription elongation factor A (SII)-like 7 56849 ENSG00000182916
48  ENSG00000136709 NA WDR33 WD repeat domain 33 55339 ENSG00000136709
49  ENSG00000196460 NA RFX8 regulatory factor X, 8 731220 ENSG00000196460
50  ENSG00000114956 NA DGUOK deoxyguanosine kinase 1716 ENSG00000114956
51  ENSG00000100307 NA CBX7 chromobox homolog 7 23492 ENSG00000100307
52  ENSG00000145545 NA SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 6715 ENSG00000145545
53  ENSG00000112640 NA PPP2R5D protein phosphatase 2, regulatory subunit B', delta 5528 ENSG00000112640
54  ENSG00000167986 NA DDB1 damage-specific DNA binding protein 1, 127kDa 1642 ENSG00000167986
55  ENSG00000196549 NA MME membrane metallo-endopeptidase 4311 ENSG00000196549
56  ENSG00000104960 NA PTOV1 prostate tumor overexpressed 1 53635 ENSG00000104960


Database:cellular component       Name:intracellular membrane-bounded organelle       ID:GO:0043231
C=9587; O=56; E=41.60; R=1.35; rawP=0.0004; adjP=0.0068
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000180104 NA EXOC3 exocyst complex component 3 11336 ENSG00000180104
2  ENSG00000174231 NA PRPF8 PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae) 10594 ENSG00000174231
3  ENSG00000119950 NA MXI1 MAX interactor 1 4601 ENSG00000119950
4  ENSG00000005955 NA GGNBP2 gametogenetin binding protein 2 79893 ENSG00000005955
5  ENSG00000109111 NA SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 6830 ENSG00000109111
6  ENSG00000088808 NA PPP1R13B protein phosphatase 1, regulatory subunit 13B 23368 ENSG00000088808
7  ENSG00000169057 NA MECP2 methyl CpG binding protein 2 (Rett syndrome) 4204 ENSG00000169057
8  ENSG00000159055 NA MIS18A MIS18 kinetochore protein homolog A (S. pombe) 54069 ENSG00000159055
9  ENSG00000177169 NA ULK1 unc-51-like kinase 1 (C. elegans) 8408 ENSG00000177169
10  ENSG00000182919 NA C11orf54 chromosome 11 open reading frame 54 28970 ENSG00000182919
11  ENSG00000119139 NA TJP2 tight junction protein 2 9414 ENSG00000119139
12  ENSG00000187954 NA CYHR1 cysteine/histidine-rich 1 50626 ENSG00000187954
13  ENSG00000012822 NA CALCOCO1 calcium binding and coiled-coil domain 1 57658 ENSG00000012822
14  ENSG00000161011 NA SQSTM1 sequestosome 1 8878 ENSG00000161011
15  ENSG00000114520 NA SNX4 sorting nexin 4 8723 ENSG00000114520
16  ENSG00000104626 NA ERI1 exoribonuclease 1 90459 ENSG00000104626
17  ENSG00000213380 NA COG8 component of oligomeric golgi complex 8 84342 ENSG00000213380
18  ENSG00000213995 NA CARKD carbohydrate kinase domain containing 55739 ENSG00000213995
19  ENSG00000183864 NA TOB2 transducer of ERBB2, 2 10766 ENSG00000183864
20  ENSG00000198408 NA MGEA5 meningioma expressed antigen 5 (hyaluronidase) 10724 ENSG00000198408
21  ENSG00000173207 NA CKS1B CDC28 protein kinase regulatory subunit 1B 1163 ENSG00000173207
22  ENSG00000241852 NA C8orf58 chromosome 8 open reading frame 58 541565 ENSG00000241852
23  ENSG00000117472 NA TSPAN1 tetraspanin 1 10103 ENSG00000117472
24  ENSG00000136854 NA STXBP1 syntaxin binding protein 1 6812 ENSG00000136854
25  ENSG00000080802 NA CNOT4 CCR4-NOT transcription complex, subunit 4 4850 ENSG00000080802
26  ENSG00000127054 NA CPSF3L cleavage and polyadenylation specific factor 3-like 54973 ENSG00000127054
27  ENSG00000079459 NA FDFT1 farnesyl-diphosphate farnesyltransferase 1 2222 ENSG00000079459
28  ENSG00000099995 NA SF3A1 splicing factor 3a, subunit 1, 120kDa 10291 ENSG00000099995
29  ENSG00000166887 NA VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 23339 ENSG00000166887
30  ENSG00000158109 NA TPRG1L tumor protein p63 regulated 1-like 127262 ENSG00000158109
31  ENSG00000164715 NA LMTK2 lemur tyrosine kinase 2 22853 ENSG00000164715
32  ENSG00000184481 NA FOXO4 forkhead box O4 4303 ENSG00000184481
33  ENSG00000105221 NA AKT2 v-akt murine thymoma viral oncogene homolog 2 208 ENSG00000105221
34  ENSG00000013374 NA NUB1 negative regulator of ubiquitin-like proteins 1 51667 ENSG00000013374
35  ENSG00000082641 NA NFE2L1 nuclear factor (erythroid-derived 2)-like 1 4779 ENSG00000082641
36  ENSG00000130939 NA UBE4B ubiquitination factor E4B 10277 ENSG00000130939
37  ENSG00000116604 NA MEF2D myocyte enhancer factor 2D 4209 ENSG00000116604
38  ENSG00000118939 NA UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 7347 ENSG00000118939
39  ENSG00000139613 NA SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 6601 ENSG00000139613
40  ENSG00000177479 NA ARIH2 ariadne homolog 2 (Drosophila) 10425 ENSG00000177479
41  ENSG00000139112 NA GABARAPL1 GABA(A) receptor-associated protein like 1 23710 ENSG00000139112
42  ENSG00000070950 NA RAD18 RAD18 homolog (S. cerevisiae) 56852 ENSG00000070950
43  ENSG00000124786 NA SLC35B3 solute carrier family 35, member B3 51000 ENSG00000124786
44  ENSG00000173011 NA TADA2B transcriptional adaptor 2B 93624 ENSG00000173011
45  ENSG00000241258 NA CRCP CGRP receptor component 27297 ENSG00000241258
46  ENSG00000197724 NA PHF2 PHD finger protein 2 5253 ENSG00000197724
47  ENSG00000182916 NA TCEAL7 transcription elongation factor A (SII)-like 7 56849 ENSG00000182916
48  ENSG00000136709 NA WDR33 WD repeat domain 33 55339 ENSG00000136709
49  ENSG00000196460 NA RFX8 regulatory factor X, 8 731220 ENSG00000196460
50  ENSG00000114956 NA DGUOK deoxyguanosine kinase 1716 ENSG00000114956
51  ENSG00000100307 NA CBX7 chromobox homolog 7 23492 ENSG00000100307
52  ENSG00000145545 NA SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 6715 ENSG00000145545
53  ENSG00000112640 NA PPP2R5D protein phosphatase 2, regulatory subunit B', delta 5528 ENSG00000112640
54  ENSG00000167986 NA DDB1 damage-specific DNA binding protein 1, 127kDa 1642 ENSG00000167986
55  ENSG00000196549 NA MME membrane metallo-endopeptidase 4311 ENSG00000196549
56  ENSG00000104960 NA PTOV1 prostate tumor overexpressed 1 53635 ENSG00000104960


Database:cellular component       Name:organelle       ID:GO:0043226
C=10651; O=60; E=46.22; R=1.30; rawP=0.0004; adjP=0.0068
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000180104 NA EXOC3 exocyst complex component 3 11336 ENSG00000180104
2  ENSG00000174231 NA PRPF8 PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae) 10594 ENSG00000174231
3  ENSG00000119950 NA MXI1 MAX interactor 1 4601 ENSG00000119950
4  ENSG00000005955 NA GGNBP2 gametogenetin binding protein 2 79893 ENSG00000005955
5  ENSG00000109111 NA SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 6830 ENSG00000109111
6  ENSG00000088808 NA PPP1R13B protein phosphatase 1, regulatory subunit 13B 23368 ENSG00000088808
7  ENSG00000169057 NA MECP2 methyl CpG binding protein 2 (Rett syndrome) 4204 ENSG00000169057
8  ENSG00000159055 NA MIS18A MIS18 kinetochore protein homolog A (S. pombe) 54069 ENSG00000159055
9  ENSG00000177169 NA ULK1 unc-51-like kinase 1 (C. elegans) 8408 ENSG00000177169
10  ENSG00000182919 NA C11orf54 chromosome 11 open reading frame 54 28970 ENSG00000182919
11  ENSG00000174442 NA ZWILCH Zwilch, kinetochore associated, homolog (Drosophila) 55055 ENSG00000174442
12  ENSG00000119139 NA TJP2 tight junction protein 2 9414 ENSG00000119139
13  ENSG00000187954 NA CYHR1 cysteine/histidine-rich 1 50626 ENSG00000187954
14  ENSG00000012822 NA CALCOCO1 calcium binding and coiled-coil domain 1 57658 ENSG00000012822
15  ENSG00000161011 NA SQSTM1 sequestosome 1 8878 ENSG00000161011
16  ENSG00000114520 NA SNX4 sorting nexin 4 8723 ENSG00000114520
17  ENSG00000104626 NA ERI1 exoribonuclease 1 90459 ENSG00000104626
18  ENSG00000213380 NA COG8 component of oligomeric golgi complex 8 84342 ENSG00000213380
19  ENSG00000213995 NA CARKD carbohydrate kinase domain containing 55739 ENSG00000213995
20  ENSG00000183864 NA TOB2 transducer of ERBB2, 2 10766 ENSG00000183864
21  ENSG00000198408 NA MGEA5 meningioma expressed antigen 5 (hyaluronidase) 10724 ENSG00000198408
22  ENSG00000173207 NA CKS1B CDC28 protein kinase regulatory subunit 1B 1163 ENSG00000173207
23  ENSG00000142661 NA MYOM3 myomesin family, member 3 127294 ENSG00000142661
24  ENSG00000241852 NA C8orf58 chromosome 8 open reading frame 58 541565 ENSG00000241852
25  ENSG00000105357 NA MYH14 myosin, heavy chain 14, non-muscle 79784 ENSG00000105357
26  ENSG00000117472 NA TSPAN1 tetraspanin 1 10103 ENSG00000117472
27  ENSG00000136854 NA STXBP1 syntaxin binding protein 1 6812 ENSG00000136854
28  ENSG00000080802 NA CNOT4 CCR4-NOT transcription complex, subunit 4 4850 ENSG00000080802
29  ENSG00000127054 NA CPSF3L cleavage and polyadenylation specific factor 3-like 54973 ENSG00000127054
30  ENSG00000079459 NA FDFT1 farnesyl-diphosphate farnesyltransferase 1 2222 ENSG00000079459
31  ENSG00000099995 NA SF3A1 splicing factor 3a, subunit 1, 120kDa 10291 ENSG00000099995
32  ENSG00000166887 NA VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 23339 ENSG00000166887
33  ENSG00000158109 NA TPRG1L tumor protein p63 regulated 1-like 127262 ENSG00000158109
34  ENSG00000164715 NA LMTK2 lemur tyrosine kinase 2 22853 ENSG00000164715
35  ENSG00000184481 NA FOXO4 forkhead box O4 4303 ENSG00000184481
36  ENSG00000105221 NA AKT2 v-akt murine thymoma viral oncogene homolog 2 208 ENSG00000105221
37  ENSG00000013374 NA NUB1 negative regulator of ubiquitin-like proteins 1 51667 ENSG00000013374
38  ENSG00000082641 NA NFE2L1 nuclear factor (erythroid-derived 2)-like 1 4779 ENSG00000082641
39  ENSG00000116871 NA MAP7D1 MAP7 domain containing 1 55700 ENSG00000116871
40  ENSG00000130939 NA UBE4B ubiquitination factor E4B 10277 ENSG00000130939
41  ENSG00000116604 NA MEF2D myocyte enhancer factor 2D 4209 ENSG00000116604
42  ENSG00000118939 NA UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 7347 ENSG00000118939
43  ENSG00000139613 NA SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 6601 ENSG00000139613
44  ENSG00000177479 NA ARIH2 ariadne homolog 2 (Drosophila) 10425 ENSG00000177479
45  ENSG00000139112 NA GABARAPL1 GABA(A) receptor-associated protein like 1 23710 ENSG00000139112
46  ENSG00000070950 NA RAD18 RAD18 homolog (S. cerevisiae) 56852 ENSG00000070950
47  ENSG00000124786 NA SLC35B3 solute carrier family 35, member B3 51000 ENSG00000124786
48  ENSG00000173011 NA TADA2B transcriptional adaptor 2B 93624 ENSG00000173011
49  ENSG00000241258 NA CRCP CGRP receptor component 27297 ENSG00000241258
50  ENSG00000197724 NA PHF2 PHD finger protein 2 5253 ENSG00000197724
51  ENSG00000182916 NA TCEAL7 transcription elongation factor A (SII)-like 7 56849 ENSG00000182916
52  ENSG00000136709 NA WDR33 WD repeat domain 33 55339 ENSG00000136709
53  ENSG00000196460 NA RFX8 regulatory factor X, 8 731220 ENSG00000196460
54  ENSG00000114956 NA DGUOK deoxyguanosine kinase 1716 ENSG00000114956
55  ENSG00000100307 NA CBX7 chromobox homolog 7 23492 ENSG00000100307
56  ENSG00000145545 NA SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 6715 ENSG00000145545
57  ENSG00000112640 NA PPP2R5D protein phosphatase 2, regulatory subunit B', delta 5528 ENSG00000112640
58  ENSG00000167986 NA DDB1 damage-specific DNA binding protein 1, 127kDa 1642 ENSG00000167986
59  ENSG00000196549 NA MME membrane metallo-endopeptidase 4311 ENSG00000196549
60  ENSG00000104960 NA PTOV1 prostate tumor overexpressed 1 53635 ENSG00000104960


Database:cellular component       Name:intracellular organelle       ID:GO:0043229
C=10636; O=60; E=46.15; R=1.30; rawP=0.0004; adjP=0.0068
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000180104 NA EXOC3 exocyst complex component 3 11336 ENSG00000180104
2  ENSG00000174231 NA PRPF8 PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae) 10594 ENSG00000174231
3  ENSG00000119950 NA MXI1 MAX interactor 1 4601 ENSG00000119950
4  ENSG00000005955 NA GGNBP2 gametogenetin binding protein 2 79893 ENSG00000005955
5  ENSG00000109111 NA SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 6830 ENSG00000109111
6  ENSG00000088808 NA PPP1R13B protein phosphatase 1, regulatory subunit 13B 23368 ENSG00000088808
7  ENSG00000169057 NA MECP2 methyl CpG binding protein 2 (Rett syndrome) 4204 ENSG00000169057
8  ENSG00000159055 NA MIS18A MIS18 kinetochore protein homolog A (S. pombe) 54069 ENSG00000159055
9  ENSG00000177169 NA ULK1 unc-51-like kinase 1 (C. elegans) 8408 ENSG00000177169
10  ENSG00000182919 NA C11orf54 chromosome 11 open reading frame 54 28970 ENSG00000182919
11  ENSG00000174442 NA ZWILCH Zwilch, kinetochore associated, homolog (Drosophila) 55055 ENSG00000174442
12  ENSG00000119139 NA TJP2 tight junction protein 2 9414 ENSG00000119139
13  ENSG00000187954 NA CYHR1 cysteine/histidine-rich 1 50626 ENSG00000187954
14  ENSG00000012822 NA CALCOCO1 calcium binding and coiled-coil domain 1 57658 ENSG00000012822
15  ENSG00000161011 NA SQSTM1 sequestosome 1 8878 ENSG00000161011
16  ENSG00000114520 NA SNX4 sorting nexin 4 8723 ENSG00000114520
17  ENSG00000104626 NA ERI1 exoribonuclease 1 90459 ENSG00000104626
18  ENSG00000213380 NA COG8 component of oligomeric golgi complex 8 84342 ENSG00000213380
19  ENSG00000213995 NA CARKD carbohydrate kinase domain containing 55739 ENSG00000213995
20  ENSG00000183864 NA TOB2 transducer of ERBB2, 2 10766 ENSG00000183864
21  ENSG00000198408 NA MGEA5 meningioma expressed antigen 5 (hyaluronidase) 10724 ENSG00000198408
22  ENSG00000173207 NA CKS1B CDC28 protein kinase regulatory subunit 1B 1163 ENSG00000173207
23  ENSG00000142661 NA MYOM3 myomesin family, member 3 127294 ENSG00000142661
24  ENSG00000241852 NA C8orf58 chromosome 8 open reading frame 58 541565 ENSG00000241852
25  ENSG00000105357 NA MYH14 myosin, heavy chain 14, non-muscle 79784 ENSG00000105357
26  ENSG00000117472 NA TSPAN1 tetraspanin 1 10103 ENSG00000117472
27  ENSG00000136854 NA STXBP1 syntaxin binding protein 1 6812 ENSG00000136854
28  ENSG00000080802 NA CNOT4 CCR4-NOT transcription complex, subunit 4 4850 ENSG00000080802
29  ENSG00000127054 NA CPSF3L cleavage and polyadenylation specific factor 3-like 54973 ENSG00000127054
30  ENSG00000079459 NA FDFT1 farnesyl-diphosphate farnesyltransferase 1 2222 ENSG00000079459
31  ENSG00000099995 NA SF3A1 splicing factor 3a, subunit 1, 120kDa 10291 ENSG00000099995
32  ENSG00000166887 NA VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 23339 ENSG00000166887
33  ENSG00000158109 NA TPRG1L tumor protein p63 regulated 1-like 127262 ENSG00000158109
34  ENSG00000164715 NA LMTK2 lemur tyrosine kinase 2 22853 ENSG00000164715
35  ENSG00000184481 NA FOXO4 forkhead box O4 4303 ENSG00000184481
36  ENSG00000105221 NA AKT2 v-akt murine thymoma viral oncogene homolog 2 208 ENSG00000105221
37  ENSG00000013374 NA NUB1 negative regulator of ubiquitin-like proteins 1 51667 ENSG00000013374
38  ENSG00000082641 NA NFE2L1 nuclear factor (erythroid-derived 2)-like 1 4779 ENSG00000082641
39  ENSG00000116871 NA MAP7D1 MAP7 domain containing 1 55700 ENSG00000116871
40  ENSG00000130939 NA UBE4B ubiquitination factor E4B 10277 ENSG00000130939
41  ENSG00000116604 NA MEF2D myocyte enhancer factor 2D 4209 ENSG00000116604
42  ENSG00000118939 NA UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 7347 ENSG00000118939
43  ENSG00000139613 NA SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 6601 ENSG00000139613
44  ENSG00000177479 NA ARIH2 ariadne homolog 2 (Drosophila) 10425 ENSG00000177479
45  ENSG00000139112 NA GABARAPL1 GABA(A) receptor-associated protein like 1 23710 ENSG00000139112
46  ENSG00000070950 NA RAD18 RAD18 homolog (S. cerevisiae) 56852 ENSG00000070950
47  ENSG00000124786 NA SLC35B3 solute carrier family 35, member B3 51000 ENSG00000124786
48  ENSG00000173011 NA TADA2B transcriptional adaptor 2B 93624 ENSG00000173011
49  ENSG00000241258 NA CRCP CGRP receptor component 27297 ENSG00000241258
50  ENSG00000197724 NA PHF2 PHD finger protein 2 5253 ENSG00000197724
51  ENSG00000182916 NA TCEAL7 transcription elongation factor A (SII)-like 7 56849 ENSG00000182916
52  ENSG00000136709 NA WDR33 WD repeat domain 33 55339 ENSG00000136709
53  ENSG00000196460 NA RFX8 regulatory factor X, 8 731220 ENSG00000196460
54  ENSG00000114956 NA DGUOK deoxyguanosine kinase 1716 ENSG00000114956
55  ENSG00000100307 NA CBX7 chromobox homolog 7 23492 ENSG00000100307
56  ENSG00000145545 NA SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 6715 ENSG00000145545
57  ENSG00000112640 NA PPP2R5D protein phosphatase 2, regulatory subunit B', delta 5528 ENSG00000112640
58  ENSG00000167986 NA DDB1 damage-specific DNA binding protein 1, 127kDa 1642 ENSG00000167986
59  ENSG00000196549 NA MME membrane metallo-endopeptidase 4311 ENSG00000196549
60  ENSG00000104960 NA PTOV1 prostate tumor overexpressed 1 53635 ENSG00000104960


Database:cellular component       Name:intracellular part       ID:GO:0044424
C=12237; O=66; E=53.10; R=1.24; rawP=0.0003; adjP=0.0068
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000180104 NA EXOC3 exocyst complex component 3 11336 ENSG00000180104
2  ENSG00000005955 NA GGNBP2 gametogenetin binding protein 2 79893 ENSG00000005955
3  ENSG00000127920 NA GNG11 guanine nucleotide binding protein (G protein), gamma 11 2791 ENSG00000127920
4  ENSG00000088808 NA PPP1R13B protein phosphatase 1, regulatory subunit 13B 23368 ENSG00000088808
5  ENSG00000187954 NA CYHR1 cysteine/histidine-rich 1 50626 ENSG00000187954
6  ENSG00000114520 NA SNX4 sorting nexin 4 8723 ENSG00000114520
7  ENSG00000104626 NA ERI1 exoribonuclease 1 90459 ENSG00000104626
8  ENSG00000183864 NA TOB2 transducer of ERBB2, 2 10766 ENSG00000183864
9  ENSG00000105357 NA MYH14 myosin, heavy chain 14, non-muscle 79784 ENSG00000105357
10  ENSG00000117472 NA TSPAN1 tetraspanin 1 10103 ENSG00000117472
11  ENSG00000099995 NA SF3A1 splicing factor 3a, subunit 1, 120kDa 10291 ENSG00000099995
12  ENSG00000100226 NA GTPBP1 GTP binding protein 1 9567 ENSG00000100226
13  ENSG00000105221 NA AKT2 v-akt murine thymoma viral oncogene homolog 2 208 ENSG00000105221
14  ENSG00000082641 NA NFE2L1 nuclear factor (erythroid-derived 2)-like 1 4779 ENSG00000082641
15  ENSG00000085741 NA WNT11 wingless-type MMTV integration site family, member 11 7481 ENSG00000085741
16  ENSG00000116604 NA MEF2D myocyte enhancer factor 2D 4209 ENSG00000116604
17  ENSG00000139112 NA GABARAPL1 GABA(A) receptor-associated protein like 1 23710 ENSG00000139112
18  ENSG00000070950 NA RAD18 RAD18 homolog (S. cerevisiae) 56852 ENSG00000070950
19  ENSG00000241258 NA CRCP CGRP receptor component 27297 ENSG00000241258
20  ENSG00000182916 NA TCEAL7 transcription elongation factor A (SII)-like 7 56849 ENSG00000182916
21  ENSG00000197724 NA PHF2 PHD finger protein 2 5253 ENSG00000197724
22  ENSG00000196460 NA RFX8 regulatory factor X, 8 731220 ENSG00000196460
23  ENSG00000114956 NA DGUOK deoxyguanosine kinase 1716 ENSG00000114956
24  ENSG00000100307 NA CBX7 chromobox homolog 7 23492 ENSG00000100307
25  ENSG00000145545 NA SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 6715 ENSG00000145545
26  ENSG00000112640 NA PPP2R5D protein phosphatase 2, regulatory subunit B', delta 5528 ENSG00000112640
27  ENSG00000104960 NA PTOV1 prostate tumor overexpressed 1 53635 ENSG00000104960
28  ENSG00000174231 NA PRPF8 PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae) 10594 ENSG00000174231
29  ENSG00000119950 NA MXI1 MAX interactor 1 4601 ENSG00000119950
30  ENSG00000109111 NA SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 6830 ENSG00000109111
31  ENSG00000169057 NA MECP2 methyl CpG binding protein 2 (Rett syndrome) 4204 ENSG00000169057
32  ENSG00000159055 NA MIS18A MIS18 kinetochore protein homolog A (S. pombe) 54069 ENSG00000159055
33  ENSG00000177169 NA ULK1 unc-51-like kinase 1 (C. elegans) 8408 ENSG00000177169
34  ENSG00000182919 NA C11orf54 chromosome 11 open reading frame 54 28970 ENSG00000182919
35  ENSG00000174442 NA ZWILCH Zwilch, kinetochore associated, homolog (Drosophila) 55055 ENSG00000174442
36  ENSG00000119139 NA TJP2 tight junction protein 2 9414 ENSG00000119139
37  ENSG00000012822 NA CALCOCO1 calcium binding and coiled-coil domain 1 57658 ENSG00000012822
38  ENSG00000161011 NA SQSTM1 sequestosome 1 8878 ENSG00000161011
39  ENSG00000213380 NA COG8 component of oligomeric golgi complex 8 84342 ENSG00000213380
40  ENSG00000213995 NA CARKD carbohydrate kinase domain containing 55739 ENSG00000213995
41  ENSG00000198408 NA MGEA5 meningioma expressed antigen 5 (hyaluronidase) 10724 ENSG00000198408
42  ENSG00000142661 NA MYOM3 myomesin family, member 3 127294 ENSG00000142661
43  ENSG00000173207 NA CKS1B CDC28 protein kinase regulatory subunit 1B 1163 ENSG00000173207
44  ENSG00000241852 NA C8orf58 chromosome 8 open reading frame 58 541565 ENSG00000241852
45  ENSG00000103264 NA FBXO31 F-box protein 31 79791 ENSG00000103264
46  ENSG00000164776 NA PHKG1 phosphorylase kinase, gamma 1 (muscle) 5260 ENSG00000164776
47  ENSG00000080802 NA CNOT4 CCR4-NOT transcription complex, subunit 4 4850 ENSG00000080802
48  ENSG00000136854 NA STXBP1 syntaxin binding protein 1 6812 ENSG00000136854
49  ENSG00000127054 NA CPSF3L cleavage and polyadenylation specific factor 3-like 54973 ENSG00000127054
50  ENSG00000079459 NA FDFT1 farnesyl-diphosphate farnesyltransferase 1 2222 ENSG00000079459
51  ENSG00000158109 NA TPRG1L tumor protein p63 regulated 1-like 127262 ENSG00000158109
52  ENSG00000166887 NA VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 23339 ENSG00000166887
53  ENSG00000164715 NA LMTK2 lemur tyrosine kinase 2 22853 ENSG00000164715
54  ENSG00000184481 NA FOXO4 forkhead box O4 4303 ENSG00000184481
55  ENSG00000013374 NA NUB1 negative regulator of ubiquitin-like proteins 1 51667 ENSG00000013374
56  ENSG00000116871 NA MAP7D1 MAP7 domain containing 1 55700 ENSG00000116871
57  ENSG00000130939 NA UBE4B ubiquitination factor E4B 10277 ENSG00000130939
58  ENSG00000139613 NA SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 6601 ENSG00000139613
59  ENSG00000118939 NA UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 7347 ENSG00000118939
60  ENSG00000177479 NA ARIH2 ariadne homolog 2 (Drosophila) 10425 ENSG00000177479
61  ENSG00000163719 NA MTMR14 myotubularin related protein 14 64419 ENSG00000163719
62  ENSG00000124786 NA SLC35B3 solute carrier family 35, member B3 51000 ENSG00000124786
63  ENSG00000173011 NA TADA2B transcriptional adaptor 2B 93624 ENSG00000173011
64  ENSG00000136709 NA WDR33 WD repeat domain 33 55339 ENSG00000136709
65  ENSG00000167986 NA DDB1 damage-specific DNA binding protein 1, 127kDa 1642 ENSG00000167986
66  ENSG00000196549 NA MME membrane metallo-endopeptidase 4311 ENSG00000196549


Database:cellular component       Name:nucleus       ID:GO:0005634
C=5955; O=40; E=25.84; R=1.55; rawP=0.0006; adjP=0.0087
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000174231 NA PRPF8 PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae) 10594 ENSG00000174231
2  ENSG00000119950 NA MXI1 MAX interactor 1 4601 ENSG00000119950
3  ENSG00000005955 NA GGNBP2 gametogenetin binding protein 2 79893 ENSG00000005955
4  ENSG00000109111 NA SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 6830 ENSG00000109111
5  ENSG00000088808 NA PPP1R13B protein phosphatase 1, regulatory subunit 13B 23368 ENSG00000088808
6  ENSG00000169057 NA MECP2 methyl CpG binding protein 2 (Rett syndrome) 4204 ENSG00000169057
7  ENSG00000159055 NA MIS18A MIS18 kinetochore protein homolog A (S. pombe) 54069 ENSG00000159055
8  ENSG00000182919 NA C11orf54 chromosome 11 open reading frame 54 28970 ENSG00000182919
9  ENSG00000119139 NA TJP2 tight junction protein 2 9414 ENSG00000119139
10  ENSG00000187954 NA CYHR1 cysteine/histidine-rich 1 50626 ENSG00000187954
11  ENSG00000012822 NA CALCOCO1 calcium binding and coiled-coil domain 1 57658 ENSG00000012822
12  ENSG00000161011 NA SQSTM1 sequestosome 1 8878 ENSG00000161011
13  ENSG00000104626 NA ERI1 exoribonuclease 1 90459 ENSG00000104626
14  ENSG00000183864 NA TOB2 transducer of ERBB2, 2 10766 ENSG00000183864
15  ENSG00000198408 NA MGEA5 meningioma expressed antigen 5 (hyaluronidase) 10724 ENSG00000198408
16  ENSG00000173207 NA CKS1B CDC28 protein kinase regulatory subunit 1B 1163 ENSG00000173207
17  ENSG00000241852 NA C8orf58 chromosome 8 open reading frame 58 541565 ENSG00000241852
18  ENSG00000080802 NA CNOT4 CCR4-NOT transcription complex, subunit 4 4850 ENSG00000080802
19  ENSG00000127054 NA CPSF3L cleavage and polyadenylation specific factor 3-like 54973 ENSG00000127054
20  ENSG00000099995 NA SF3A1 splicing factor 3a, subunit 1, 120kDa 10291 ENSG00000099995
21  ENSG00000184481 NA FOXO4 forkhead box O4 4303 ENSG00000184481
22  ENSG00000105221 NA AKT2 v-akt murine thymoma viral oncogene homolog 2 208 ENSG00000105221
23  ENSG00000013374 NA NUB1 negative regulator of ubiquitin-like proteins 1 51667 ENSG00000013374
24  ENSG00000082641 NA NFE2L1 nuclear factor (erythroid-derived 2)-like 1 4779 ENSG00000082641
25  ENSG00000130939 NA UBE4B ubiquitination factor E4B 10277 ENSG00000130939
26  ENSG00000116604 NA MEF2D myocyte enhancer factor 2D 4209 ENSG00000116604
27  ENSG00000118939 NA UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 7347 ENSG00000118939
28  ENSG00000139613 NA SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 6601 ENSG00000139613
29  ENSG00000177479 NA ARIH2 ariadne homolog 2 (Drosophila) 10425 ENSG00000177479
30  ENSG00000070950 NA RAD18 RAD18 homolog (S. cerevisiae) 56852 ENSG00000070950
31  ENSG00000173011 NA TADA2B transcriptional adaptor 2B 93624 ENSG00000173011
32  ENSG00000241258 NA CRCP CGRP receptor component 27297 ENSG00000241258
33  ENSG00000197724 NA PHF2 PHD finger protein 2 5253 ENSG00000197724
34  ENSG00000182916 NA TCEAL7 transcription elongation factor A (SII)-like 7 56849 ENSG00000182916
35  ENSG00000136709 NA WDR33 WD repeat domain 33 55339 ENSG00000136709
36  ENSG00000196460 NA RFX8 regulatory factor X, 8 731220 ENSG00000196460
37  ENSG00000112640 NA PPP2R5D protein phosphatase 2, regulatory subunit B', delta 5528 ENSG00000112640
38  ENSG00000100307 NA CBX7 chromobox homolog 7 23492 ENSG00000100307
39  ENSG00000167986 NA DDB1 damage-specific DNA binding protein 1, 127kDa 1642 ENSG00000167986
40  ENSG00000104960 NA PTOV1 prostate tumor overexpressed 1 53635 ENSG00000104960


Database:cellular component       Name:pre-autophagosomal structure       ID:GO:0000407
C=15; O=2; E=0.07; R=30.73; rawP=0.0019; adjP=0.0242
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000177169 NA ULK1 unc-51-like kinase 1 (C. elegans) 8408 ENSG00000177169
2  ENSG00000161011 NA SQSTM1 sequestosome 1 8878 ENSG00000161011


Database:cellular component       Name:autophagic vacuole       ID:GO:0005776
C=32; O=2; E=0.14; R=14.40; rawP=0.0085; adjP=0.0963
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000177169 NA ULK1 unc-51-like kinase 1 (C. elegans) 8408 ENSG00000177169
2  ENSG00000139112 NA GABARAPL1 GABA(A) receptor-associated protein like 1 23710 ENSG00000139112


Database:cellular component       Name:macromolecular complex       ID:GO:0032991
C=3864; O=25; E=16.77; R=1.49; rawP=0.0188; adjP=0.1471
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000100226 NA GTPBP1 GTP binding protein 1 9567 ENSG00000100226
2  ENSG00000166887 NA VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 23339 ENSG00000166887
3  ENSG00000174231 NA PRPF8 PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae) 10594 ENSG00000174231
4  ENSG00000184481 NA FOXO4 forkhead box O4 4303 ENSG00000184481
5  ENSG00000127920 NA GNG11 guanine nucleotide binding protein (G protein), gamma 11 2791 ENSG00000127920
6  ENSG00000169057 NA MECP2 methyl CpG binding protein 2 (Rett syndrome) 4204 ENSG00000169057
7  ENSG00000177169 NA ULK1 unc-51-like kinase 1 (C. elegans) 8408 ENSG00000177169
8  ENSG00000130939 NA UBE4B ubiquitination factor E4B 10277 ENSG00000130939
9  ENSG00000139613 NA SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 6601 ENSG00000139613
10  ENSG00000174442 NA ZWILCH Zwilch, kinetochore associated, homolog (Drosophila) 55055 ENSG00000174442
11  ENSG00000164050 NA PLXNB1 plexin B1 5364 ENSG00000164050
12  ENSG00000139112 NA GABARAPL1 GABA(A) receptor-associated protein like 1 23710 ENSG00000139112
13  ENSG00000114520 NA SNX4 sorting nexin 4 8723 ENSG00000114520
14  ENSG00000104626 NA ERI1 exoribonuclease 1 90459 ENSG00000104626
15  ENSG00000213380 NA COG8 component of oligomeric golgi complex 8 84342 ENSG00000213380
16  ENSG00000173011 NA TADA2B transcriptional adaptor 2B 93624 ENSG00000173011
17  ENSG00000241258 NA CRCP CGRP receptor component 27297 ENSG00000241258
18  ENSG00000105357 NA MYH14 myosin, heavy chain 14, non-muscle 79784 ENSG00000105357
19  ENSG00000103264 NA FBXO31 F-box protein 31 79791 ENSG00000103264
20  ENSG00000136854 NA STXBP1 syntaxin binding protein 1 6812 ENSG00000136854
21  ENSG00000164776 NA PHKG1 phosphorylase kinase, gamma 1 (muscle) 5260 ENSG00000164776
22  ENSG00000100307 NA CBX7 chromobox homolog 7 23492 ENSG00000100307
23  ENSG00000112640 NA PPP2R5D protein phosphatase 2, regulatory subunit B', delta 5528 ENSG00000112640
24  ENSG00000167986 NA DDB1 damage-specific DNA binding protein 1, 127kDa 1642 ENSG00000167986
25  ENSG00000099995 NA SF3A1 splicing factor 3a, subunit 1, 120kDa 10291 ENSG00000099995




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).